2-(N-Boc-amino)pyridine-5-boronic acid pinacol ester - Names and Identifiers
Name | tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate
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Synonyms | LogP 6-Boc-AMinopyridine-3-boronic acid pinacol ester Boc-6-Aminopyridine-3-boronic acid pinacol ester 2-(N-Boc-amino)pyridine-5-boronic acid pinacol ester tert-butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylcarbamate tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate tert-butyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate [5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyridin-2-yl]carbamic acid tert-butyl ester CarbaMic acid, N-[5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-, 1,1-diMethylethyl ester
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CAS | 910462-31-6
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InChI | InChI=1/C16H25BN2O4/c1-14(2,3)21-13(20)19-12-9-8-11(10-18-12)17-22-15(4,5)16(6,7)23-17/h8-10H,1-7H3,(H,18,19,20) |
2-(N-Boc-amino)pyridine-5-boronic acid pinacol ester - Physico-chemical Properties
Molecular Formula | C16H25BN2O4
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Molar Mass | 320.19 |
Density | 1.10±0.1 g/cm3(Predicted) |
Boling Point | 394.5±27.0 °C(Predicted) |
Flash Point | 192.4°C |
Vapor Presure | 1.97E-06mmHg at 25°C |
pKa | 12.69±0.70(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.503 |
2-(N-Boc-amino)pyridine-5-boronic acid pinacol ester - Risk and Safety
Hazard Symbols | Xi - Irritant
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Risk Codes | 43 - May cause sensitization by skin contact
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Safety Description | 36/37 - Wear suitable protective clothing and gloves.
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2-(N-Boc-amino)pyridine-5-boronic acid pinacol ester - Introduction
tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate is an organic compound. The following is a detailed description of its nature, use, formulation and safety information:
Nature:
-Chemical formula: C18H27BN2O3
-Molecular weight: 334.23g/mol
-Appearance: White or off-white solid
-Melting Point: 78-80°C
-Storage conditions: Store in a cold dark place
Use:
- tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate are often used as reagents in organic synthesis, especially in pharmaceutical synthesis.
-It can be used as an intermediate for potential anticancer agents and bioactive molecules.
-This compound can also be used as research and development of new drugs and organic compounds.
Method:
The preparation of tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate usually involves the following steps:
1. 2-Picolinic acid is first treated as the acid chloride.
2. then react with 4,4,5,5-tetramethyl -1,3,2-dioxodioxyboron detoxycycloacetone (TMDB) to generate 2-pyridine -5-boronic acid pinacol ester.
3. Finally, the BOC protecting group is reacted with 2-pyridine-5-boronic acid pinacol ester to give the tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]carbamate.
Safety Information:
- tert-butyl [5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl] The safety of carbamate has not been fully studied. General laboratory safety practices should be observed when handling and storing this compound.
-Avoid contact with skin, eyes and mucous membranes. In case of contact, rinse immediately with plenty of water.
-Pay attention to good ventilation conditions during operation to avoid inhaling harmful gases.
-Follow chemical safety practices during handling and storage to ensure safe storage and disposal.
Last Update:2024-04-09 21:00:56